The eighth edition of Design and Analysis of Experiments continues to provide extensive and in-depth information on engineering, business, and statistics-as well as informative ways to help readers design and analyze experiments for improving the quality, efficiency and performance of working systems. Furthermore, the text maintains its comprehensive coverage by including: new examples, exercises, and problems (including in the areas of biochemistry and biotechnology); new topics and problems in the area of response surface; new topics in nested and split-plot design; and the residual maximum likelihood method is now emphasized throughout the book